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Events Rensselaer at Hartford’s Computer Science Seminar Series Presents, "Five Hierarchical Levels of Sequence-Structure Correlation in Proteins" EVENT: Christopher Bystroff, Ph.D., Assistant Professor, Rensselaer Polytechnic Institute, will present a seminar titled, "Five Hierarchical Levels of Sequence-Structure Correlation in Proteins." The presentation is part of Rensselaer at Hartford’s Computer Science Seminar Series. DATE: Friday, January 30, 2004 TIME: 6 p.m. LOCATION: Seminar Hall, Rensselaer at Hartford, 275 Windsor Street, Hartford ADMISSION: FREE! Open to the public. All are welcome to attend. TOPIC DISCUSSION: This is a review of recent work toward modeling protein folding pathways using a bioinformatics approach. Statistical models have been developed for sequence-structure correlations in proteins at five levels of structural complexity: (1) short motifs, (2) extended motifs, (3) non-local pairs of motifs, (4) three dimensional arrangements of multiple motifs, and (5) global structural homology. Here we review statistical models including sequence profiles, hidden Markov models, and interaction potentials for the first four levels of structural detail: the I-sites Library models local structure motifs; HMMSTR in a hidden Markov model for extended motifs; HMMSTR-CM, a model for pairwise interactions between motifs; and SCALI-HMM, a set of hidden Markov models for spatial arrangements of motifs. Global sequence models have been extensively reviewed elsewhere and will not be discussed. The parallels between the statistical models and the theoretical models for folding pathways will be examined. ABOUT THE SPEAKER: Dr. Bystroff (www.bioinfo.rpi.edu/~bystrc/index.html) joined the biology department at Rensselaer in 1999 after holding research positions in California and Washington. He also spent three years teaching and conducting research as a Fulbright fellow in Managua, Nicaragua. Dr. Bystroff has co-authored numerous papers on protein structure analysis and prediction, and has given more than twenty invited lectures on the subject. He is co-founder of the Center for Bioinformatics at Rensselaer and Wadsworth and runs the world’s only public Web site for ab initio protein structure prediction at: www.bioinfo.rpi.edu/~bystrc/hmmstr/server.php. MORE INFORMATION: For more information about the event, please contact Lynn A. DeNoia, Ph.D., Professor, Department of Engineering and Science, Rensselaer at Hartford, at (860) 548-7804 or e-mail: denoial@ewp.rpi.edu.
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